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产品型号：UA040099
更新时间：2025-08-11
厂商性质：生产厂家
访问量：54
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蛋白
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Insulin-like growth factor I （IGF-I） belongs tothe family of insulin-like growth factors that are structurally homologous toproinsulin. Mature IGFs are generated by proteolytic processing of inactiveprecursor protein containing N-terminal and C-terminal propeptide regions.IGF-1 is produced primarily by the liver as an endocrine hormone as well as intarget tissues in a paracrine/autocrine fashion. The production of IGF-1 isstimulated by growth hormone （GH） and can be retarded by undernutrition, growthhormone insensitivity, lack of growth hormone receptors, or failures of thedownstream signaling pathway post GH receptor including SHP2 and STAT5B. IGF1binds IGF-1R, IGF-2R, and the insulin receptor and plays a key role in cellcycle progression, cell proliferation and tumor progression.
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产品型号：UA040099
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