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Macrophage-Colony Stimulating Factor (M-CSF),
also known as Colony Stimulating Factor-1 (CSF-1), is a hematopoietic growth
factor. It can stimulate the survival, proliferation and differentiation of
mononuclear phagocytes, in addition to the spreading and motility of
macrophages. M-CSF is mainly produced by monocytes, macrophages, fibroblasts,
and endothelial cells. M-CSF interaction with its receptor, c-fms, has been
implicated in the growth, invasion, and metastasis of several diseases,
including breast and endometrial cancers.