13774214275
13774214275
产品中心
产品型号：S0B5460
更新时间：2025-08-08
厂商性质：生产厂家
访问量：60
服务热线15855403091
CD4 is a glycoprotein expressed on the surface of certain immune cells, most notably helper T cells. It is a member of the immunoglobulin superfamily and has four immunoglobulin-like domains （D1 to D4）. CD4 acts as a co-receptor with the T-cell receptor （TCR） to recognize antigens displayed by MHC class II molecules on antigen-presenting cells. The D1 domain of CD4 binds to the β2 region of MHC class II, bringing the TCR complex and CD4 into close proximity. This allows the tyrosine kinase Lck, bound to the cytoplasmic tail of CD4, to phosphorylate tyrosine residues on the cytoplasmic domains of CD3, amplifying the signal generated by the TCR. CD4 is also the primary receptor for the human immunodeficiency virus （HIV）, and its interaction with the HIV gp120 protein is a key step in viral entry.
当前位置：
上一个：
返回列表
