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更新时间：2025-08-09
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This gene encodes a member of the SOX （SRY-related HMG-box） family of transcription factors involved in the regulation of embryonic development and determination of cell fate. The encoded protein acts as a transcriptional activator after forming a protein complex with other proteins. This protein acts as a nucleocytoplasmic shuttle protein and is important for neural crest and peripheral nervous system development. SOX10 is used as an immunohistochemistry marker, diagnosis of malignant melanoma; Combined with MITF1 and it can differentiate malignant melanoma in situ from actinic keratosis; More specific for tumors originating from the neural crest than S100.
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