B7-H3 Recombinant Rabbit mAb (SDT-249-26)

产品型号：S0B2244

更新时间：2025-08-09

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ELISA试剂盒抗体试剂盒二抗试剂盒二抗其它流式抗体琼脂糖/磁珠偶联抗体抗Payload抗体泛修饰抗体标签/内参抗体功能性抗体 Biosimilar抗体偶联抗体配对抗体病理/IHC抗体

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产品介绍

B7-H3 is a 316 amino acid-long type I transmembrane protein, existing in two isoforms determined by its extracellular domain. In humans it consists of one pair （2Ig-B7-H3） or two identical pairs （4Ig-B7-H3） due to exon duplication.
B7-H3 mRNA is expressed in most normal tissues. In contrast, B7-H3 protein has a very limited expression on normal tissues because of its post-transcriptional regulation by microRNAs. However, B7-H3 protein is expressed at high frequency on many different cancer types （60% of all cancers）. In non-malignant tissues, B7-H3 has a predominantly inhibitory role in adaptive immunity, suppressing T cell activation and proliferation. In malignant tissues, B7-H3 is an immune checkpoint molecule that inhibits tumor antigen-specific immune responses. B7-H3 also possesses non-immunological pro-tumorigenic functions such as promoting migration, invasion, angiogenesis, chemoresistance, epithelial-to-mesenchymal transition, and affecting tumor cell metabolism.

上一个：S0B2248ATRX 重组兔单抗(SDT-458-37)