13774214275
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更新时间：2025-08-10
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p63 （TAp63） is closely related to p40 （ΔNp63） as both proteins represent isoforms of the p63 gene with distinct molecular functions. While “full length" p63 （TAp63） activates p53 target genes such as p21 or BAX, the shorter transcript p40 （ΔNp63） inhibits activation of p53 and “full length" p63. Among carcinomas, p40 has approximately the same sensitivity as p63 but a higher specificity, as the TAp63 isoform is expressed more widespread in eg., adenocarcinomas. Moreover, p63 occur in lymphomas that are p40 negative.
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