13774214275
13774214275
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更新时间：2025-10-08
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CD11b and CD11c are integral components of the integrin family, which are heterodimeric transmembrane glycoproteins involved in cell adhesion and immune responses. CD11b, also known as integrin alpha M （ITGAM） or Mac-1, pairs with CD18 to form complement receptor 3 （CR3）, playing a crucial role in mediating the uptake of complement-coated particles and pathogens. It is expressed on various immune cells, including macrophages, monocytes, granulocytes, and NK cells. Similarly, CD11c, also called integrin alpha X （ITGAX）, forms complement receptor 4 （CR4） with CD18 and is involved in similar adhesive interactions and phagocytosis. Both CD11b and CD11c are commonly used as markers for immune cells, with CD11b/c antibodies often employed in research to identify microglia in the brain and other immune cells.
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