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Oligodendrocyte lineage transcription factor 2 (OLIG2) is a member of a family of basic helix–loop–helix (bHLH) transcription factors. OLIG2 is expressed only in the central nervous system (CNS) and plays an important role in the development of brain cancers. Tissue specificity: Expressed in the brain, in oligodendrocytes. Strongly expressed in oligodendrogliomas, while expression is weak to moderate in astrocytomas. Expression in glioblastomas highly variable.