Anti-FGFR Monoclonal Antibody（Aprutumab）

Fibroblast growth factor receptor 2 （FGFR2） also known as CD332 （cluster of differentiation 332） is a protein that in humans is encoded by the FGFR2 gene residing on chromosome 10.[5][6] FGFR2 is a receptor for fibroblast growth factor. FGFR2 has important roles in embryonic development and tissue repair, especially bone and blood vessels. Like the other members of the fibroblast growth factor receptor family, these receptors signal by binding to their ligand and dimerisation （pairing of receptors）, which causes the tyrosine kinase domains to initiate a cascade of intracellular signals. On a molecular level these signals mediate cell division, growth and differentiation. Recombinant Human monoclonal antibody expressed in HEK293 binding to Human FGFR2. This is a novel fibroblast growth factor receptor 2 （FGFR2） directed antibody used for cancer therapy. FGFR2 is expressed in a range of tumor types such as gastric, breast, HNSCC, pancreatic and ovarian cancers. FGFR2 has been described to promote tumor growth and survival and play a role in chemotherapy resistance.