13774214275
13774214275
产品中心
产品型号：S0B1556
更新时间：2025-08-09
厂商性质：生产厂家
访问量：62
服务热线15855403091
Proto-oncogene c-KIT is the gene encoding the receptor tyrosine kinase protein known as tyrosine-protein kinase KIT, CD117 （cluster of differentiation 117） or mast/stem cell growth factor receptor （SCFR）. Altered forms of this receptor may be associated with some types of cancer. KIT is a receptor tyrosine kinase type III, which binds to stem cell factor, also known as "steel factor" or "c-kit ligand" and expressed on the surface of hematopoietic stem cells as well as other cell types. When this receptor binds to stem cell factor （SCF） it forms a dimer that activates its intrinsic tyrosine kinase activity, that in turn phosphorylates and activates signal transduction molecules that propagate the signal in the cell. After activation, the receptor is ubiquitinated to mark it for transport to a lysosome and eventual destruction. Signaling through KIT plays a role in cell survival, proliferation, and differentiation. For instance, KIT signaling is required for melanocyte survival, and it is also involved in haematopoiesis and gametogenesis.
当前位置：
上一个：
返回列表
